Real quick; in order to run the debugger in Visual Studio 2005 on Windows Vista, you need to run the application as an administrator.  For the past few days, I've been doing this by right clicking the Visual Studio shortcut in my start menu and selecting "Run as Administrator".  What I really want is for Windows Vista to remember that I always want to run this program as an administrator.  So after a quick check I found that you can set it in the properties to do just that.

To be sure it works consistently, I changed the properties on the actual application found in: Program Files\Microsoft Visual Studio 8\Common7\IDE

Only problem I found that I haven't figured out yet (mostly for lack of trying) is that opening a solution file (.sln) directly does not work.  Actually, it doesn't do anything; no prompts or IDE.  But for now, it's one less click.